In New York City, Yankee Stadium, home of Major League Baseball's New York Yankees, opens with the Yankees beating their eternal rivals the Boston Red Sox 4 to 1. The stadium, which is nicknamed The House that Ruth Built, sees the Yankees become the most successful franchise in baseball history. It is eventually replaced by a new Yankee Stadium and closes in September 2008.

A group of CIA financed and trained Cuban refugees lands at the Bay of Pigs in southern Cuba with the aim of ousting Fidel Castro. However, the invasion fails badly and the result is embarrassment for U.S. president John F. Kennedy and a major boost in popularity for Fidel Castro, and also has the effect of pushing him toward the Soviet Union for protection.

Swiss scientist Albert Hofmann, while working at Sandoz Laboratories in Basel, accidentally absorbs lysergic acid diethylamide, better known as LSD, and thus discovers its psychedelic properties. He had first synthesized the substance five years earlier but hadn't been aware of its effects. He goes on to write scores of articles and books about his creation.